Binding Kinetics In Transcription Activation And Repression - Transcription Regulation Is A Key Determinant Of How…

Purpose

Department of Health and Human Services awarded $2.5M to New York University for Binding kinetics in transcription activation and repression - transcription regulation is a key determinant of how genetic variability is interpreted by a cell: more than 90% of traits- and disease-associated genetic variants map outside of the coding genome. while we now have a robust understanding of where human tfs might bind, enabling predictions of tf binding when data is unavailable, those approaches do not tell us how frequently a tf binds, how long it stays bound, and what it does once bound, which makes it difficult to predict the impact that tf or regulatory site variants will have on transcription. critical regulatory architectures, primarily studied with activators,…